| Not only caffeine but other drugs as well shown to increase nicotine consumption in animals include pentobarbital, methadone, amphetamines, and heroininally, there is the effect of tobacco itself. Smokers have significantly lower levels of monoamine oxidase-B, the enzyme responsible for breaking down dopamine in the brain. As a result, they are able to sustain higher levels of dopamine for longer periods of time, particularly if they continue smoking. |  |
Elevated dopamine means elevated pleasure; nicotine works synergistically with alcohol, cannabis, cocaine, and narcotics to provide a sustained high. Hence alcohol, caffeine and other drug users tend to smoke more heavily.
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